There are skincare ingredients that suddenly seem to appear everywhere, and then there are innovations that make beauty people stop and ask how they actually work. PDRN and spicules definitely fall into the second category.
Mary&May has brought the two together in its new Spicule PDRN Cream Collection, with three versions built around familiar powerhouse ingredients: Collagen, Azelaic Acid, and Retinol. Instead of simply adding another active cream to an already crowded skincare shelf, the concept is about helping those targeted ingredients penetrate the skin more effectively for visible results.
So, What Exactly Are Spicules?
Spicules are microscopic, needle-like structures that have become an increasingly talked-about delivery technology in Korean skincare. Unlike an actual needle treatment, they’re incorporated into topical formulas and create a characteristic fine prickling or tingling sensation on the skin.
The idea is to improve the way a formula interacts with the skin and help its targeted skincare ingredients penetrate more effectively.
That’s what makes Mary&May’s approach interesting. Rather than putting PDRN into one generic formula, the brand has paired its spicule PDRN technology with different actives so a routine can be selected according to a specific skincare goal.
Why PDRN Is Having a Beauty Moment
PDRN has become one of the most talked-about ingredients to emerge from Korean skincare, particularly in products focused on revitalizing the appearance of tired or compromised-looking skin.
That makes its pairing with spicule technology a logical next step: one ingredient category is associated with skin renewal and conditioning, while the delivery system is designed to help the formula get where it needs to go more effectively.
Mary&May then adds another layer by offering three different targeted versions.
Collagen: For Skin That Could Use Some Bounce

Collagen Spicule PDRN Cream
The Collagen Spicule PDRN Cream is the one that will immediately catch the attention of anyone whose skincare priorities include firmness, elasticity and a plumper appearance.
Collagen has been a beauty staple forever, but putting it into this newer PDRN-spicule format gives the familiar ingredient a much more contemporary treatment. It’s particularly appealing for skin that is beginning to look less resilient, less supple or simply tired.
Azelaic Acid: When Clarity Is the Priority

Azelaic Acid Spicule PDRN Cream
The Azelaic Acid Spicule PDRN Cream takes the collection in another direction.
Azelaic acid has earned a loyal following because it works particularly well in routines focused on clearer, more even-looking skin. It’s one of those ingredients that isn’t necessarily as glamorous as whatever is currently exploding on social media, but knowledgeable skincare users tend to appreciate it.
Pairing it with Mary&May’s PDRN and spicule technology makes this an especially interesting option for anyone whose concerns center on visible unevenness, texture and overall clarity.
Retinol: The Serious Skin-Renewal Option

Retinol Spicule PDRN Cream
Then there’s Retinol Spicule PDRN Cream, which brings one of skincare’s best-known renewal ingredients into the collection.
Retinol is already associated with improving the appearance of texture, fine lines and uneven-looking skin over time. Combining it with the collection’s PDRN and spicule concept makes this the obvious choice for someone looking for a more age-conscious, renewal-focused routine.
As with any retinol product, introducing it thoughtfully rather than piling it on alongside every other potent active in the bathroom cabinet is the smarter beauty move.
A More Customized Way to Use a Beauty Trend
Perhaps the best thing about Mary&May’s collection is that it doesn’t treat PDRN as though simply putting those four letters on a jar is enough.
The Collagen, Azelaic Acid and Retinol Spicule PDRN Creams give consumers a reason to choose according to what their skin actually needs. It’s a more intelligent approach to a trend: interesting technology, recognizable targeted ingredients and three distinctly different skincare directions.
For beauty followers who have been curious about both PDRN and the growing spicule skincare category, Mary&May has managed to put them together in a way that feels genuinely current.

